Pharmacological Treatment of Malaria

Management of uncomplicated Malaria:

Drug of choice for treatment of uncomplicated malaria is Artemether-Lumefantrine (AL), which is a fixed formulation of artemether 20mg and lumefantrine 120mg or dispersible tablets for paediatric use

Use of Artemether-lumefantrine (ALu) in Pregnancy

·         Presently, Artemisinin compounds cannot be recommended for treatment of malaria in the first trimester of pregnancy.

·         In the first trimester of pregnancy quinine should be used as first line treatment.

·         After the first trimester ALu tablets is first line medicine.

Use of Artemether-lumefantrine (ALu) in Lactation

·         Due to the long elimination half-life of Lumefantrine (up to 10 days), it is not recommended in mothers breast-feeding children below 5kgs.
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·         In this case quinine should be used.

Management of Severe Malaria:

·         Parenteral artesunate  Dosage: 2.4 mg/kg in body weight. IV or IM given on admission (time = 0 hour), then at 12 hours and 24 hours for a minimum of 3 injections in 24 hours regardless of patient’s recovery

·         Alternatively; Injectable Artemether should be administered in a dose of 3.2mg/kg body weight loading dose IM stat then 1.6mg/kg bwt (time= 0 hrs, then 24hrs then 48 hrs)

Person Getting His Blood Check


Wells BG, DiPiro J, Schwinghammer T (2013), Pharmacotherapy Handbook (6th Ed). New York, NY: McGraw-Hill.

DiPiro JT, Talbert RL, Yee GC, Matzke GR, Wells BG, Posey ML, (2008): Pharmacotherapy: A Pathophysiologic Approach (7th ed): New York, NY: McGraw-Hill.
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Katz M D., Matthias KR., Chisholm-Burns M A., Pharmacotherapy(2011) Principles & Practice Study Guide: A Case-Based Care Plan Approach: New York, NY: McGraw-Hill.

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