Treatment regimens
The drugs and dosages for PB and MB for both adults and children are shown below:
Adults (MB)
Monthly treatment: Day 1
Rifampicin 600 mg (2 x 300 mg)
Clofazimine 300 mg (3 x 100 mg)
Dapsone 100 mg
Daily treatment: Days 2–28
Clofazimine 50 mg
Dapsone 100 mg
Duration of treatment
12 blister packs (Figure 13) to be taken within a period of 12-18 months.
Children 10-14 years (MB)
Monthly treatment: Day 1
Rifampicin 450 mg (3 x 150 mg)
Clofazimine 150 mg (3 x 50 mg)
Dapsone 50 mg
Daily treatment: Days 2–28
Clofazimine 50 mg every other day
Dapsone 50 mg daily
Duration of treatment
12 blister packs to be taken within a period of 12-18 months.
Adults (PB)
Monthly treatment: Day 1
Rifampicin 600 mg (2 x 300 mg)
Dapsone 100 mg
Daily treatment: Days 2–28
Dapsone 100 mg
Duration of treatment
Six blister packs (Figure 14) to be taken within a period of 6–9 months.
Children 10-14 years (PB)
Monthly treatment: Day 1
Rifampicin 450 mg (3 x 150 mg)
Dapsone 50 mg
Daily Treatment: Days 2–28
Dapsone 50 mg
Duration of treatment
Six blister packs to be taken within a period of 6–9 months.
Note: Adjust the dose appropriately for a child (PB) younger than 10 years. For example, dapsone 25 mg daily and rifampicin 300 mg given once a month under supervision.
References
Wells BG, DiPiro J, Schwinghammer T (2013), Pharmacotherapy Handbook (6th Ed). New York, NY: McGraw-Hill.
DiPiro JT, Talbert RL, Yee GC, Matzke GR, Wells BG, Posey ML, (2008): Pharmacotherapy: A Pathophysiologic Approach (7th ed): New York, NY: McGraw-Hill.
Katz M D., Matthias KR., Chisholm-Burns M A., Pharmacotherapy(2011) Principles & Practice Study Guide: A Case-Based Care Plan Approach: New York, NY: McGraw-Hill.
Schwinghammer TL, Koehler JM (2009) Pharmacotherapy Casebook: A Patient-Focused Approach (7th ed): New York, NY: McGraw-Hill.