Pharmacological Treatment of Leprosy - All Global Updates

Pharmacological Treatment of Leprosy

Treatment regimens

The drugs and dosages for PB and MB for both adults and children are shown below:

Adults (MB)

Monthly treatment: Day 1

Rifampicin 600 mg (2 x 300 mg)

Clofazimine 300 mg (3 x 100 mg)

Dapsone 100 mg

Daily treatment: Days 2–28

Clofazimine 50 mg

Dapsone 100 mg

Duration of treatment

12 blister packs (Figure 13) to be taken within a period of 12-18 months.

Children 10-14 years (MB)

Monthly treatment: Day 1

Rifampicin 450 mg (3 x 150 mg)

Clofazimine 150 mg (3 x 50 mg)

Dapsone 50 mg


Daily treatment: Days 2–28

Clofazimine 50 mg every other day

Dapsone 50 mg daily


Duration of treatment

12 blister packs to be taken within a period of 12-18 months.

Adults (PB)
Monthly treatment: Day 1
Rifampicin 600 mg (2 x 300 mg)

Dapsone 100 mg


Daily treatment: Days 2–28

Dapsone 100 mg


Duration of treatment

Six blister packs (Figure 14) to be taken within a period of 6–9 months.

Children 10-14 years (PB)

Monthly treatment: Day 1

Rifampicin 450 mg (3 x 150 mg)

Dapsone 50 mg


Daily Treatment: Days 2–28

Dapsone 50 mg

Duration of treatment

Six blister packs to be taken within a period of 6–9 months.

Note: Adjust the dose appropriately for a child (PB) younger than 10 years. For example, dapsone 25 mg daily and rifampicin 300 mg given once a month under supervision.

Bunch of White Oval Medication Tablets and White Medication Capsules

References
Wells BG, DiPiro J, Schwinghammer T (2013), Pharmacotherapy Handbook (6th Ed). New York, NY: McGraw-Hill.


DiPiro JT, Talbert RL, Yee GC, Matzke GR, Wells BG, Posey ML, (2008): Pharmacotherapy: A Pathophysiologic Approach (7th ed): New York, NY: McGraw-Hill.

Katz M D., Matthias KR., Chisholm-Burns M A., Pharmacotherapy(2011) Principles & Practice Study Guide: A Case-Based Care Plan Approach: New York, NY: McGraw-Hill.


Schwinghammer TL, Koehler JM (2009) Pharmacotherapy Casebook: A Patient-Focused Approach (7th ed): New York, NY: McGraw-Hill.

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